| Info. | Vol.15 - No.1 (2021.03.20) |
|---|---|
| Title | Neuroscience Research using Small Animals on a Chip: From Nematodes to Zebrafish Larvae |
| Authors | Pushkar Bansal1, Abhinav Abraham1, Jay Garg2 and Erica E. Jung1,2(ejung72@uic.edu) |
| Institutions | 1Department of Mechanical and Industrial Engineering, The University of Illinois at Chicago, 842 W. Taylor St., Chicago, IL 60607, USA 2Department of Bioengineering, The University of Illinois at Chicago, 851 S. Morgan St., Chicago, IL 60607, USA |
| Abstract | Implementation of microfluidic technology to study small animal models such as Caenorhabditis elegans worms (soil-dwelling nematodes), Drosophila melanogaster (fruit fly) and larvae of Danio rerio (zebrafish) provides great opportunities for in vivo quantification of neuronal activities and behavioral responses. By controlling the internal environment, microfluidic devices can manipulate animal models with precision and cause minimal damage to the specimen. Due to these advantages, microfluidic devices have been applied to high-throughput drug screening, high-throughput brain-wide activity mapping, analyzing animals’ neuronal and behavioral responses to different external stimuli, microinjection, and neuronal regeneration. In this paper, we review different microfluidic devices and techniques that allow the manipulation of small animal models to study brain functions and behavioral responses. Furthermore, biomedical applications of microfluidic systems, technical challenges, and future directions in the whole brain and animal research on a chip will be discussed. |
| Keyword | Caenorhabditis elegans · Drosophila melanogaster · Danio rerio · Microfluidics · Animal models · Neuroscience · Brain imaging · Behavioral assay · Neural activity |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
