| Info. | Vol.17 - No.3 (2023.09.20) |
|---|---|
| Title | Real-Time Detection of SARS-CoV-2 Nucleocapsid Antigen Using Data Analysis Software and IoT-Based Portable Reader with Single-Walled Carbon Nanotube Field Effect Transistor |
| Authors | Da Eun Oh 1, Ji Sun Kim2, In Kyoung Hwang 2, Hong-Seog Park 2, Chang-Seuk Lee 3*, Tae Hyun Kim 1*
Da Eun Oh : First author. *Chang-Seuk Lee cslee.chem@swu.ac.kr *Tae Hyun Kim thkim@sch.ac.kr |
| Institutions | 1 Department of Chemistry, Soonchunhyang University, Asan 31538,Republic of Korea
2 GnCBio, 36, Banseok-Ro, Yuseong-Gu, Daejeon, Republic of Korea 3 Department of Chemistry, Seoul Women’s University, Seoul 01797, Republic of Korea |
| Abstract | Early detection of COVID-19 is crucial for pandemic control, necessitating the development of accurate, rapid, portable, and point-of-care testing devices. In this paper, we present a novel system comprising a carbon nanotube fi eld-effect transistor (swCNT-FET) biosensor functionalized with SARS-CoV-2 nucleocapsid protein antibody (Ab-NP), an IoT-based portable reader, and data analysis software for real-time COVID-19 detection. The Ab-NP functionalized swCNT-FET designed to transduce the biological binding event between COVID-NP and Ab-NP into an electrical signal. A microcontroller-based portable reader, designed to meet the biosensor’s signal acquisition specifications, was implemented. The suggested system, incorporates Ab-NP/swCNT-FET, IoT-based portable reader, and data processing software, was successful detection of COVID-NP at fM concentrations, highlighting its potential for clinical applications. |
| Keyword | COVID-19, Rapid antigen testing, Field-effect transistor, Data analysis software, IoT-based portable reader, Biosensor |
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