| Info. | Vol.18 - No.1 (2024.03.20) |
|---|---|
| Title | Advances in Technical Assessment of Spiral Inertial Microfluidic Devices Toward Bioparticle Separation and Profi ling: A Critical Review |
| Authors | Mahsa Bagi1,2, Fatemeh Amjad 3, Seyed Majid Ghoreishian4, Somayeh Sohrabi Shahsavari1, Yun Suk Huh5*, Mostafa Keshavarz Moraveji1*, Sirivatch Shimpalee3*
Fatemeh Amjad, Seyed Majid Ghoreishian and Somayeh Sohrabi contributed equally to this work. *Yun Suk Huh yunsuk.huh@inha.ac.kr *Mostafa Keshavarz Moraveji moraveji@aut.ac.ir *Sirivatch Shimpalee shimpale@cec.sc.edu |
| Institutions | 1 Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran
2Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA 3 Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran 4Department of Chemical Engineering, University of South Carolina, Columbia, SC, USA 5NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea |
| Abstract | Separation of micro- and nano-sized bioparticles is essential for efficient diagnostics, chemical and biological analyses, drug development, food and chemical processing, and environmental monitoring. However, most of the currently available bio- separation techniques are based on the membrane filtration approach, whose efficiency is restricted by membrane-related disadvantages, including pore size, surface charge density, and biocompatibility, which results in a reduction in the isolation resolution. To address these issues, till now, many microfluidic devices have been developed for particle/cell profiling due to their excellent sensitivity and specificity, less sample consumption, shortened processing time, and high throughput features. Of the various microfluidic systems, the spiral inertial microfluidic technique has recently attracted attention as an innovative strategy and advanced cutting-edge technology toward bioparticle separation. Depending on the needs of the microfluidic device, the spiral inertial chip can be customized to separate bioparticles owing to their sizes and different shapes. In this review, we discuss the kinematics of microchannel particle separation mechanisms, recent developments in the inertial microfluidic device realm, and their applications for the separation of several types of bioparticles, including blood cells, stem cells, sperm cells, pathogens, and algae. Finally, we highlight challenges and economical perspectives associated with guidelines for further development of spiral inertial microfluidic devices in the future. |
| Keyword | Separation · Bioparticle · Micro-channel · Cell · Spiral microfluidics |
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