| Info. | Vol.1 - No.2 (2007.06.20) |
|---|---|
| Title | Site-specific Anti-adsorptive Passivation in Microchannels |
| Authors | Sangyun Park1, Hee Chan Kim1 & Taek Dong Chung2 |
| Institutions | 1Department of Biomedical Engineering, Seoul National University, Seoul, Korea 2School of Chemistry, Seoul National University, Seoul, Korea Correspondence and requests for materials should be addressed to H.C. Kim (hckim@snu.ac.kr) & T.D. Chung (tdchung@snu.ac.kr) |
| Abstract | A novel methodology for generating site-specific anti-adsorptive coatings on microchannel walls was reported. The coating process consists of two steps. The first step is to coat the glass channel wall with linker molecules of TMSMA. And then the anti-adsorptive polymer, PEGMA, is photo-grafted onto the surface via a UV induced radical reaction using a patterned photo mask. We evaluated the proposed anti-adsorptive coating method by investigating the adsorption behavior of BSA-FITC and amine-modified polystyrene beads. This method offers valuable advantages because the coating process is carried out after the entire chip fabrication steps have been completed. The functional materials of interest could be grafted onto the microchannel wall which is difficult to access mechanically. Moreover, this method enables site-specific multiple materials coating preserving the organic layers undamaged during the chip fabrication processes. |
| Keyword | Antifouling, PEG, Surface coating, Photo grafting, Protein, Microfluidics |
| PDF File |
|
