| Info. | Vol.4 - No.1 (2010.03.20) |
|---|---|
| Title | Proteomic analysis of rat liver proteins differentially induced by trichloroethylene |
| Authors | Seul-Ki Park1, Suk-Woo Nam2, Jae-Chun Ryu3, Joo-Hyun Ham4 & Mi-Young Lee1 |
| Institutions | 1Department of Medical Biotechnology, SoonChunHyang University, Asan, Chungnam 336-600, Korea 2Department of Pathology, Catholic University, Seoul 137-701, Korea 3Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and Technology, P. O. Box 131, Cheongnyangni-dong, Seoul 130-650, Korea 4Department of Health Management, Hanseo University, Seosan 360-706, Korea Correspondence and requests for materials should be addressed to M.-Y. Lee (miyoung@sch.ac.kr) |
| Abstract | Trichloroethylene (TCE), a volatile and lipophilic solvent widely used in industrial degreasing applications, is believed to be toxic in humans. To identify possible protein biomarkers of early TCE-induced hepatotoxicity, we treated rats with a single dose of TCE equivalent to 10% of LD50 and analyzed their liver proteomes 72 h after dosing. We identified eight liver proteins that exhibited a TCE-induced change in expression level of at least 2-fold; three of these proteins were upregulated and the rest were downregulated. Because these proteins changed significantly in abundance in the absence of notable hepatotoxicity in vivo, they may be useful as one of the candidates of early predictive biomarkers of TCE exposure in rats. |
| Keyword | Trichloroethylene, Proteomics, Differential expression, Rat |
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