| Info. | Vol.7 - No.4 (2013.12.20) |
|---|---|
| Title | Transcriptomic analysis of the bitter taste receptor-mediated glucagon-like peptide-1 stimulation effect of quinine |
| Authors | Ki-Suk Kim1,??/sup>, Nam Hyun Cha2,??/sup>, Koh-Woon Kim1, Min Hee Shin1, Kang-Hoon Kim1, In-Seung Lee1, Won-Seok Chung1, Mi-Yeon Song1 & Hyeung-Jin Jang1 |
| Institutions | 1College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Heogi-dong, Dongdaemun-gu, Seoul 130-701, Korea 2Nursing Department, College of Health Science, Kangwon University |
| Abstract | Quinine is a bitter taste receptor agonist that has been studied its anti-pyretic, anti-malarial, antipain, and anti-inflammatory activity. In this study, glucagon- like peptide-1 (GLP-1) stimulation effect of quinine was investigated. Bitter taste receptors are G protein- coupled receptor (GPCR), which transfer the molecular signal through its downstream cascade. The activation of bitter taste receptor, which expressed in the enteroendocrine L cells, stimulates the GLP-1 secretion and therefore can be a therapeutic target of the type-2 diabetes mellitus (T2DM). Here, we studied GLP-1 stimulation effect of quinine on the endocrine differentiated NCI H716 cells. To investigate the molecular mode-of-action of the GLP 1 stimulation effect of quinine in the enteroendocrine L cells, transcriptomic analysis was performed. Our data suggest that quinine stimulates the GLP-1 secretion through the bitter taste receptor-signaling pathway, and thus has the possibility of therapeutic agent of T2DM. |
| Keyword | Quinine, Bitter taste receptor, Glucagonlike peptide-1 (GLP-1), Enteroendocrine L cell, Type-2 diabetes mellitus, Microarray |
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