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(사)한국바이오칩학회 The Korean BioChip Society

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Info. Vol.12 - No.4 (2018.12.20)
Title Development of the Microfluidic Device to Regulate Shear Stress Gradients
Authors Tae Hyeon Kim1, Jong Min Lee1, Christian D. Ahrberg2 & Bong Geun Chung1,*
Institutions 1Department of Mechanical Engineering, Sogang University, Seoul 04107, Republic of Korea
2Research Center, Sogang University, Seoul 04107, Republic of Korea
*Correspondence and requests for materials should be addressed to B.G. Chung (bchung@sogang.ac.kr)
Abstract Shear stress occurs in flowing liquids, especially at the interface of a flowing liquid and a stationary solid phase. Thus, it occurs inside the artery system of the human body, where it is responsible for a number of biological functions. The shear stress level generally remains less than 70 dyne/cm2 in the whole circulatory system, but in the stenotic arteries, which are constricted by 95%, a shear stress greater than 1,000 dyne/cm2 can be reached. Methods of researching the effects of shear stress on cells are of large interest to understand these processes. Here, we show the development of a microfluidic device for generating shear stress gradients. The performance of the shear stress gradient generator was theoretically simulated prior to experiments. Through simple manipulations of the liquid flow, the shape and magnitude of the shear stress gradients can be manipulated. Our microfluidic device consisted of five portions divided by arrays of micropillars. The generated shear stress gradient has five distinct levels at 8.38, 6.55, 4.42, 2.97, and 2.24 dyne/ cm2. Thereafter, an application of the microfluidic device was demonstrated testing the effect of shear stress on human umbilical vein endothelial cells.
Keyword Microfluidic device, Shear stress, Micropillar
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