| Info. | Vol.2 - No.3 (2008.09.20) |
|---|---|
| Title | Electrochemical Aptamer-based Biosensors |
| Authors | Yeon Seok Kim1, Su Jin Lee1 & Man Bock Gu1 |
| Institutions | 1College of Life Sciences and Biotechnology, Korea University,
Anam-dong, Seongbuk-gu, Seoul 136-701, Korea Correspondence and requests for materials should be addressed to M.-B. Gu (mbgu@korea.ac.kr) |
| Abstract | Aptamers are newly emerged sensing elements that are competitive with or sometimes even better than antibodies due to their various advantages: a compact size, cost effectiveness, chemical stability, in vitro synthesis, easy modification, labeling and so on. Therefore, there have recently been intensive advances in aptamer-based biosensors including electrochemical aptasensors that are more proper to the miniaturization and integration of biosensors for high-throughput analysis and point-of-care (POC). In this review, we have summarized new state of the art strategies for an aptamer-based electrochemical sensing platform and manners of signal amplification in the categories of simple label-free electrochemical detection, electrochemical signal amplification using enzymes or nanoparticles, target-induced conformational changes, and displacement formats. |
| Keyword | Aptamer, Biosensor, Aptasensor, Electrochemical, Signal amplification |
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