| Info. | Vol.3 - No.2 (2009.06.20) |
|---|---|
| Title | Anti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC) |
| Authors | Yudi Rahmawan1,2, Kyung-Jin Jang1, Myoung-Woon Moon2, Kwang-Ryeol Lee2& Kahp-Yang Suh1 |
| Institutions | 1School of Mechanical and Aerospace Engineering and the Institute of Advanced Machinery and Design, Seoul National University, Seoul 151-742, Korea 2Convergence Technology Laboratory, Korea Institute of Science and Technology, Seoul 130-650, Korea Correspondence and requests for materials should be addressed to M.-W. Moon (mwmoon@kist.re.kr) and K.-Y. Suh (sky4u@snu.ac.kr) |
| Abstract | The textured surface with superhydrophobic nature was explored for an anti-biofouling template. Hierarchical structures composed of the nano-scale wrinkle covering on micro-scale polymer pillar patterns were fabricated by combining the deposition of a thin coating layer of biocompatible diamond-like carbon (DLC) and the replica molding of poly-(dimethylsiloxane) (PDMS) micro-pillars. The as- prepared surfaces were shown to have extreme hydrophobicity (static contact angle>160o) owing to low surface energy (24.2 mN/m) and dual- roughness structures of the DLC coating. It was explored that the hierarchical surfaces showed poor adhesion of the Calf Pulmonary Artery Endothelial (CPAE) cells for cultures of 7 days suggesting that the 3-dimensional (3-D) patterned superhydrophobic DLC coating exhibits excellent anti-biofouling properties against non-specific cell adhesion. In particular, the reduced filopodia extension during cell growth was caused by disconnected focal adhesions on the pillar pattern. This limited cell adhesion could prevent undesired growth and proliferation of biological species on the surface of biomedical devices such as stents, implants or even injection syringes. |
| Keyword | Diamond-Like Carbon (DLC), Cell adhesion, Superhydrophobicity, Dual-scale structure, Anti-biofouling |
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