Info.
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Vol.4 - No.2 (2010.06.20) |
Title
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A study on cancer-cell invasion based on multi-physics analysis technology
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Authors
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Zhang Linan1 , Jihwan Song1 & Dongchoul Kim1 |
Institutions
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1Department of Mechanical Engineering, Sogang University,
1 Shinsoo-dong, Mapo-go, Seoul, Korea
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Abstract
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In this paper, a three-dimensional haptotaxis model to simulate the migration of a population of cancer cells has been proposed. The invasion of cancer cells is related with the hapto-attractant and the effect of the interface energies between the cells and the ECM. The diffuse interface model, which
incorporates the haptotaxis mechanism and interface energies, is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation. The simulation results thoroughly reveal the dynamics of cancer-cell migration.
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Keyword
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Haptotaxis, Cancer cells, Cell migration, Interface energy, Diffuse interface model
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PDF File
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