| Info. | Vol.10 - No.4 (2016.12.20) |
|---|---|
| Title | Engineered Nanofluidic Preconcentration Devices by Ion Concentration Polarization |
| Authors | Seok Young Son1, Sangjun Lee1, Hyomin Lee1,2 & Sung Jae Kim1,3,4,* |
| Institutions | 1Department of Electrical and Computer Engineering, Seoul National
University, Seoul 08826, Korea 2Institute of Advanced Machines and Design, Seoul National University, Seoul 08826, Korea 3Big Data Institute, Seoul National University, Seoul 08826, Korea 4Inter-university Semiconductor Research Center, Seoul National University, Seoul 08826, Korea *Correspondence and requests for materials should be addressed to S.J. Kim (gates@snu.ac.kr) |
| Abstract | A nanofluidic preconcentration device utilizing an ion concentration polarization (ICP) phenomenon has been regarded as one of the most efficient mechanism for preconcentrating low abundant molecules to be detected. In this review, a short fundamental aspect behind ICP was introduced and detailed engineering endeavors to enhance the performance of the preconcentration device were followed. While a conventional nanostructure based on silicon or glass substrate lose its ion-selectivity at a physiologically relevant electrolyte concentration, Nafion as a highly charged nanoporous material would maintain its permselectivity at the concentration so that various fabrication processes utilizing Nafion were introduced. In order to extend the capability of the device in terms of preconcentration factor and throughput, dual gates, ?쏹??shaped and one-channel device were shown with their pros and cons. Last section would introduce the most recent development of preconcentration mechanism; the simultaneous preconcentration with separation, the radial preconcentration and the two stressfree preconcentration mechanisms. Conclusively, this review would not only provide the key insight of development history of the nanofluidic preconcentration device but also contribute for creating the next generation preconcentration mechanisms. |
| Keyword | Nanofluidics, Nano-electrokinetics, Ion concentration polarization, Analyte preconcentration, Nano-fabrication |
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