| Info. | Vol.13 - No.3 (2019.09.20) |
|---|---|
| Title | Generation of 3D Microparticles in Microchannels with Non-rectangular Cross Sections |
| Authors | Sung Min Nam1,†, Kibeom Kim2,†, Il-Suk Kang3, Wook Park2,* & Wonhee Lee1,4,* |
| Institutions | 1Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea 2Department of Electronic Engineering, Institute for Wearable Convergence Electronics, Kyung Hee University, 1732, Deogyeongdaero, Giheung, Yongin 17104, Republic of Korea 3National Nanofab Center, KAIST, Daejeon 34141, Republic of Korea 4Department of Physics, KAIST, Daejeon 34141, Republic of Korea †These authors contrilbuted equally. *Correspondence and requests for materials should be addressed to W. Park (parkwook@khu.ac.kr) and W. Lee (whlee153@kaist.ac.kr) |
| Abstract | Flow lithography in a conventional rectangular microchannel is limited to fabrication of particles for which only the shapes of top perimeters are controlled. We present a flow lithography technique for fabrication of microparticles of diverse 3D shapes and multiple layers using non-rectangular microchannels with designed cross sections that allow the creation of complex shapes and diverse cross- sectional shapes. Variations in cross-sectional shape allow high-throughput, on-demand production of microparticles in unconventional shapes such as tetrahedrons and pyramids. Multilayered 3D particles were generated in an enlarging triangular channel combined with on-chip PDMS valves, which allow particle alignment and fluid exchange. These 3D microparticles are expected to further expand the wide variety of applications of microparticles, especially in drug delivery and tissue engineering fields. |
| Keyword | Flow lithography, Microparticle, Microfabrication |
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