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Info. Vol.13 - No.4 (2019.12.20)
Title Biologically Benign Multi-functional Mesoporous Silica Encapsulated Gold/Silver Nanorods for Anti-bacterial Applications by On-demand Release of Silver Ions
Authors Seokyoung Yoon1,†, Younghwan Chung2,†, Jin Woong Lee2, Junhyuck Chang2, Jeon Geon Han2 & Jung Heon Lee1,2,3,4,*
Institutions 1SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea
2School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea
3Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea
4Advanced Materials Technology Research Center, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea
These authors contrilbuted equally.
*Correspondence and requests for materials should be addressed to J.H.Lee (jhlee7@skku.edu)
Abstract Although silver (Ag)-based nanoparticles (NPs) are frequently used for bactericidal purposes, they have critical issues including excessive release of Ag+, severe oxidation, and cytotoxicity. In this study, we designed a multifunctional, on-demand antibacterial agent by successively encapsulating bimetallic gold/silver nanorods (Ag/AgNRs) with mesoporous silica (mSiO2) shells. Au/AuNRs were synthesized by coating Ag on AuNRs in a controlled manner, so that they exhibited a localized surface plasmon resonance peak in the near-infrared (NIR) region. When Au/AgNR@mSiO2 NPs were irradiated with an NIR laser under optimal conditions (0.4 W/cm2), they generated a small amount of heat (40–45 oC), which successively triggered the release of Ag+ and induced bacterial cell death. Here, mSiO2 shells play critical roles because they not only protect Ag from oxidation but also prevent the burst release of Ag+ and improve biocompatibility of the antibacterial agent against normal cells. We found that this multifunctional bacterial agent effectively kills gram-negative Escherichia coli and gram-positive Staphylococcus aureus without significantly increasing the temperature of the medium. Au/AgNR@mSiO2 NPs were also biologically benign with high biocompatibility against mammalian cells.
Keyword Gold/Silver nanorod, Mesoporous silica, Antibacterial agent, Drug delivery, Near-infrared (NIR), Controlled silver release, Biocompatibility
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