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Info. Vol.14 - No.4 (2020.12.20)
Title Simulation Guided Microfluidic Design for Multitarget Separation Using Dielectrophoretic Principle
Authors Mohamed Zackria Ansar B.I.1, Vineet Tirth2,3, Caffiyar Mohamed Yousuff1,*, Neeraj Kumar Shukla4, Saiful Islam5, Kashif Irshad6 & Mohammed Aarif K.O.1
Institutions "1Department of Electronics and Communication Engineering, C. Abdul Hakeem College of Engineering and Technology, Melvisharam, Tamil Nadu, India
2Mechanical Engineering Department, College of Engineering, King Khalid University, Abha-61411, Kingdom of Saudi Arabia
3Research Center for Advanced Materials Science (RCAMS), PO Box 9004, Abha-61413, Asir, Kingdom of Saudi Arabia
4Electrical Engineering Department, College of Engineering, King Khalid University, Abha-61411, Asir, Kingdom of Saudi Arabia
5Department of Civil Engineering, Universiti Tecknologi Malaysia, Johar Bahru, Malaysia
6Center of Research Excellence in Renewable Energy (CoRE-RE), King Fahd University of Petroleum & Minerals, Dhahran, 31261, Kingdom of Saudi Arabia
*Correspondence and requests for materials should be addressed to Caffiyar Mohamed Yousuff (cmd.yousuf@gmail.com) "
Abstract Microfluidic technologies have emerged as a potential tool for point of care - diagnostics and therapeutics applications. Isolation of multi-targets (Cancer cells along with platelets, red blood cells (RBCs), white blood cells (WBCs), and antigen-presenting cells (APCs)) simultaneously is of great interest in drug discovery and medical diagnosis. By utilizing dielectrophoresis (DEP) effect inside the micro channel, several attempts were made to separate binary mixtures by precisely controlling and manipulating the motion of the particles. However, all of these methods limit its applicability for multi-target particle separation in a single run. In this paper, we attempt to develop a simulation model with novel electrode arrangements to isolate multiple particles using negative DEP. Our proposed model establishes criteria for separating micron- sized particle mixtures (3μm, 7μm, 15μm, 20μm, 25μm) with various electrode shapes, electrode potentials, inlet velocities, and channel widths. The device efficiency was evaluated for a triangular electrode, square-shaped electrode, and rectangular electrode under various practical design constraints. Our study demonstrates an optimum solution for effective separation of particle mixtures using triangular electrode arrangements (utilizing less voltage) and a wider channel of 300μm width that eventually avoid channel clogging issues due to cells inside main channel and collection channels. While evaluating the separation efficiency of the proposed design, we observe that platelets, RBCs, WBCs, APCs, and CTCs experienced distinct DEP force on each, allowing them to collect in different collection outlets without any crossmixing. Hence our proposed design allows flexibility to the researchers working on DEP by using a wider channel with triangular electrode arrangements enabling them to fabricate the device under resourcelimited constraints
Keyword Dielectrophoresis, Multiple particles, Wider channel, Electrode configurations, Applied electric potentials, Flow rate
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