| Info. | Vol.15 - No.1 (2021.03.20) |
|---|---|
| Title | Multiplex Molecular Point‑of‑Care Test for Syndromic Infectious Diseases |
| Authors | Hanbi Kim1,2, Hee Jae Huh3, Eunkyoung Park1,2, Doo‑Ryeon Chung4,5,6(dr.chung@samsung.com) and Minhee Kang1,2(minhee.kang@samsung.com) |
| Institutions | 1Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul 06351, South Korea 2Department of Medical Device Management and Research, SAIHST (Samsung Advanced Institute for Health Sciences & Technology), Sungkyunkwan University, Seoul 06355, South Korea 3Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea 4Center for Infection Prevention and Control, Samsung Medical Center, Seoul 06351, South Korea 5Asia Pacific Foundation for Infectious Diseases (APFID), Seoul 06367, South Korea 6Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea |
| Abstract | Point-of-care (POC) molecular diagnostics for clinical microbiology and virology has primarily focused on the detection of a single pathogen. More recently, it has transitioned into a comprehensive syndromic approach that employs multiplex capabilities, including the simultaneous detection of two or more pathogens. Multiplex POC tests provide higher accuracy to for actionable decisionmaking in critical care, which leads to pathogen-specific treatment and standardized usages of antibiotics that help prevent unnecessary processes. In addition, these tests can be simple enough to operate at the primary care level and in remote settings where there is no laboratory infrastructure. This review focuses on state-of-the-art multiplexed molecular point-of-care tests (POCT) for infectious diseases and efforts to overcome their limitations, especially related to inadequate throughput for the identification of syndromic diseases. We also discuss promising and imperative clinical POC approaches, as well as the possible hurdles of their practical applications as front-line diagnostic tests. |
| Keyword | Multiplex molecular point-of-care testing · Syndromic infectious disease · Molecular diagnosis · POCT |
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