| Info. | Vol.15 - No.3 (2021.09.20) |
|---|---|
| Title | Electrochemical Microbiosensor for Detecting COVID-19 in a Patient Sample Based on Gold Microcuboids Pattern |
| Authors | Waleed A. El-Said1 · Abdullah S. Al‐Bogami1 · Wael Alshitari1 · Deia A. El-Hady1 · Tamer S. Saleh1 · Mohamed A. El-Mokhtar2 · Jeong-Woo Choi3 |
| Institutions | *Waleed A. El-Said waahmed@uj.edu.sa
*Jeong-Woo Choi jwchoi@sogang.ac.kr 1Department of Chemistry, College of Science, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi Arabia 2Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt 3Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul 04107, Republic of Korea |
| Abstract | As continues increasing the COVID-19 infections, there is an urgent need for developing fast, simple, selective, and accurate COVID-19 biosensors. A highly uniform gold (Au) microcuboid pattern was used as a microelectrode that allowed monitoring a small analyte. The electrochemical biosensor was used to monitor the COVID-19 S protein within a concentration range from 100 to 5 pmol L −1 ; it showed a lower detection limit of 276 fmol L −1 . Finally, the developed COVID-19 sensor was used to detect a positive sample from a human patient obtained through a nasal swab; the results were confirmed using the PCR technique. The results showed that the SWV technique showed high sensitivity towards detecting COVID-19 and good efficiency for detecting COVID-19 in a positive human sample. |
| Keyword | COVID-19 · Gold microelectrode · Cyclic voltammetry · Square wave voltammetry · Electrochemical biosensor · Raman spectroscopy · Nasal swab |
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