Info.
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Vol.15 - No.4 (2021.12.20) |
Title
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Recent Developments in Surface Topography-Modulated Neurogenesis
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Authors
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Chaima Amri1, Tae-Hyung Kim2,* & Jin-Ho Lee1,3,*
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Institutions
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1Department of Convergence Medical Sciences, School of Medicine, Pusan National University, Yangsan 50612, Korea
2School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
3School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Korea |
Abstract
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"Repairing a nervous system damaged following an injury or as a consequence of neurodegeneration is still a challenging task.
Yet, topography-based tissue engineering of neurons from different cell sources has demonstrated promising potential in the field. Substrate patterning through a range of methods including photolithography, nanofibers electrospinning, or microimprinting can not only impact the maturity of these vital neural cells but can also orient the differentiation of neural stem cells, a more prolific source of neurons. Furthermore, it has been shown that topography can guide the trans-differentiation of mesenchymal stem cells, a readily accessible cell source, towards a neuronal fate. Thus, in this review, we will cover the most recent methods used in topography-based neural tissue engineering."
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Keyword
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Tissue engineering, Topography, Neurons, Neural network, Stem cells, Trans-differentiation
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PDF File
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