| Info. | Vol.16 - No.1 (2022.03.20) |
|---|---|
| Title | Nano-biomarker-Based Surface-Enhanced Raman Spectroscopy for Selective Diagnosis of Gallbladder and Liver Injury |
| Authors | Sanghwa Lee1, Eunyoung Tak2, Yu Jeong Cho3,4, Jiye Kim2, Jooyoung Lee2, Ryunjin Lee2, Kwanhee Lee2, Minsung Kwon2, Young-In Yoon5, Sung-Gyu Lee5, Jung-Man Namgoong4 & Jun Ki Kim1,2 |
| Institutions | * Jung-Man Namgoong namgoong2940@gmail.com * Jun Ki Kim kim@amc.seoul.kr 1 Biomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Republic of Korea 2 Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea 3 Department of Surgery, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri 11923, South Korea 4 Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea 5 Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea |
| Abstract | During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor and recipient. Early detection and treatment of complications after surgery by evaluating the function of blood vessels and the biliary tract is crucial. A biosensing chip that can monitor patient health status from the bile excreted during the recovery process has been developed using a surface-enhanced Raman sensing chip. Surface-enhanced Raman spectroscopy signals of bile obtained from normal bile duct ligation and gallbladder damage mouse models using a cautery device were identified and analyzed. The surface-enhanced Raman chip with a nanometer-level porous structure can selectively separate the nanometer biomarkers and measure the Raman signal. Through the detection of nanometer biomarkers in the bile and comparative analysis of histopathology, the Raman signal in the damaged gallbladder was compared with that caused by liver damage due to bile duct ligation, showing that it becomes a biosensing chip for monitoring recovery. |
| Keyword | Bile duct ligation, Gallbladder cauterization, Surface-enhanced Raman spectroscopy, Nano-biomarker, Principal component analysis |
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