| Info. | Vol.16 - No.2 (2022.06.20) |
|---|---|
| Title | Nanoplasmonic Sensor Chip Readable in a Conventional Plate Reader |
| Authors | Hee-Kyung Na1, Chang-Hyuk Yoo2,3, Jun-Kyu Choi2, Jong G. Ok4, Choong-Heui Chung5, Jung-Sub Wi5
*Jung-Sub Wi jungsub.wi@hanbat.ac.kr |
| Institutions | 1 Safety Measurement Institute, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea 2 Small Machines Co., Ltd, Seoul 04808, Republic of Korea 3 Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea 4 Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea 5 Department of Materials Science and Engineering, Hanbat National University, Daejeon 34158, Republic of Korea |
| Abstract | In this report, we present a straightforward method for bridging a nanoplasmonic sensor with a conventional plate reader. By attaching lithographically prepared plasmonic nanostructures to a commercially available microwell strip, which has a perforated bottom, we could measure highly sensitive optical signals of plasmonic nanostructures using a conventional plate reader. The absorbance measurements and electromagnetic simulations show that a proper alignment between light polarization and the plasmonic nanostructure improves the sensing performance, which can be achieved with a linear polarizing film. Furthermore, the multiplexed detection capability of the proposed nanoplasmonic sensor chip was successfully demonstrated by monitoring four different enzyme–substrate reactions. These results illustrate the potential of the proposed nanoplasmonic sensor chip, which can combine advanced nanoplasmonic sensors with the well-developed microwell plate reader. |
| Keyword | LSPR · Sensor · Plate reader · Gold · Plasmonic · Nanostructure |
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