| Info. | Vol.16 - No.3 (2022.09.20) |
|---|---|
| Title | 3D Artificial Cell Membranes as Versatile Platforms for Biological Applications |
| Authors | Won Bae Han1,2, Dong-Hyun Kang1,3, Tae Song Kim1,* *Tae Song Kim tskim@kist.re.kr |
| Institutions | 1Creative Research Center for Brain Science, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
2KU-KIST Graduate School of Converging Science and Technology , Korea University , 145 Anam-ro, Seongbuk-gu , Seoul 02841 , Republic of Korea 3Micro Nano Fab Center , Korea Institute of Science and Technology , 5, Hwarang-ro 14-gil, Seongbuk-gu , Seoul 02792 , Republic of Korea |
| Abstract | Artificial cell membranes, emulating biological membranes, have been used to elucidate the physiological functions of cells and realize biological applications. Advanced methodologies, along with considerations of biological/functional aspects, have enabled the development of various forms/types of artificial cell membranes commonly based on a lipid bilayer. Previous review articles have extensively explored 2-dimensional membranes but lack consideration on 3-dimensional membranes, which exhibit many advantages for biological platforms, such as large surface area, high stability, and ease of observation. Indeed, 3-dimensional membranes can accommodate a higher population of membrane proteins and show a more sensitive response to analytes than planar membranes. This review highlights the developments of artificial cell membranes in terms of structures and fabrication strategies, with a focus on 3-dimensional free-standing lipid membranes, and concludes with remarks on current key issues and challenges to evolve artificial cell membranes to another level. |
| Keyword | Artificial cell membrane · 3D structures · Lipids · Membrane proteins · Biosensors |
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