| Info. | Vol.16 - No.3 (2022.09.20) |
|---|---|
| Title | Magnetic Nanochain-Based Smart Drug Delivery System with Remote Tunable Drug Release by a Magnetic Field |
| Authors | Byunghoon Kang1,2,3, Moo-Kwang Shin2, Seungmin Han2,4, Ilyoung Oh5, Eunjung Kim6,7, Joseph Park3, Hye Young Son8,9, Taejoon Kang1, Juyeon Jung1, Yong-Min Huh8,9,10,*, Seungjoo Haam2,*, & Eun-Kyung Lim1,11,*
*Yong-Min Huh ymhuh@yuhs.ac.kr *Seungjoo Haam haam@yonsei.ac.kr *Eun-Kyung Lim eklim1112@kribb.re.kr |
| Institutions | 1Korea Research Institute of Bioscience and Biotechnology (KRIBB), Bionanotechnology Research Center, 125
Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
2Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul 03722, Republic of Korea 3Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA 4Division of Cardio-Thoracic Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA 5Department of Information Electronic Engineering, Dongyang Mirae University, 445 Gyoungin-ro, Guro-gu, Seoul 08221, Republic of Korea 6Department of Bioengineering & Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea 7Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea 8Department of Radiology, College of Medicine, Yonsei University, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul 03722, Republic of Korea 9Severance Biomedical Science Institute, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seoul 03722, Republic of Korea 10YUHS-KRIBB Medical Convergence Research Institute, 50-1 Yonsei-ro, Seoul 03722, Republic of Korea 11Department of Nanobiotechnology, KRIBB School of Biotechnology, UST, 217, Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea |
| Abstract | Considerable attention is given to drug delivery technology that efficiently delivers appropriate levels of drug molecules to diseased sites with significant therapeutic efficacy. Nanotechnology has been used to develop various strategies for targeted drug delivery, while controlling the release of drugs because of its many benefits. Here, a delivery system was designed to control drug release by external magnetic fields using porous silica and magnetic nanoparticles. Magnetic nanochains (MNs) of various lengths (MN-1: 1.4 ± 0.8 μm, MN-2: 2.2 ± 1.1 μm, and MN-3: 5.3 ± 2.0 μm) were synthesized by controlling the exposure time of the external magnetic force in magnetic nanoaggregates (MNCs). Mesoporous silica-coated magnetic nanochains (MSMNs) (MSMN-1, MSMN-2, and MSMN-3) were prepared by forming a porous silica layer through sol–gel polymerization. These MSMNs could load the drug doxorubicin (DOX) into the silica layer (DOX-MSMNs) and control the release behavior of the DOX through an external rotating magnetic field. Simulations and experiments were used to verify the motion and drug release behavior of the MSMNs. Furthermore, a bio-receptor (aptamer, Ap) was introduced onto the surface of the DOX-MSMNs (Ap-DOX-MSMNs) that could recognize specific cancer cells. The Ap-DOX-MSMNs demonstrated a strong therapeutic effect on cancer cells that was superior to that of the free DOX. The potent ability of these MSMNs as an external stimulus-responsive drug delivery system was proven. |
| Keyword | Magnetic field · Magnetic nanochain · Remote tunable · Drug release · External triggering · Smart drug delivery |
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