| Info. | Vol.16 - No.4 (2022.12.20) |
|---|---|
| Title | Microfabricated Stretching Devices for Studying the Effects of Tensile Stress on Cells and Tissues |
| Authors | Jaewon Kim1, Sein Kim2, Shahab Uddin3, Sung Sik Lee4, Sungsu Park1,2,3
*Sungsu Park nanopark@skku.edu |
| Institutions | 1School of Mechanical Engineering, Sungkyunkwan University, Suwon 16419, Korea
2Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Korea 3Department of Biophysics, Sungkyunkwan University, Suwon 16419, Korea 4ScopeM (Scientific Center of Optical and Electron Microscopy), Institute of Biochemistry, ETH Zurich, HPM C52.2, Otto-Stern-Weg 3, CH-8093 Zurich, Switzerland |
| Abstract | Tensile stress is one of the most common mechanical stresses on the connective tissues of human organs. Cell stretching devices have been developed to study the effects of tensile stress on cells and tissues. In this study, we review how these devices function mechanically and apply them to biological research. To this end, we technically evaluate the four types of actuation processes used in cell stretching devices, including electric motor-driven and electromagnetic actuation, along with their pros and cons. For example, these cell stretching devices have shortcomings including large size, a complicated system, and generation of heat and shock, which hinder the real-time imaging of cells during stretching in high-resolution microscopes. We also describe the effects of tensile stress on cellular and tissue homeostasis. With this review, we seek to explore future directions for development of cell tensioning devices to understand mechanobiological responses to mechanical stress in vivo. |
| Keyword | Tensile stress, Stretching device, Mechanotransduction, Tensional homeostasis, Epithelial-mesenchymal transition |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
