| Info. | Vol.16 - No.4 (2022.12.20) |
|---|---|
| Title | Current Advances in Paper-Based Biosensor Technologies for Rapid COVID-19 Diagnosis |
| Authors | Soohyun Kim1, Jong-Hwan Lee1
*Jong-Hwan Lee jonghwan@krict.re.kr |
| Institutions | 1Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea |
| Abstract | The global coronavirus disease 2019 (COVID-19) pandemic has had significant economic and social impacts on billions of people worldwide since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, in November 2019. Although polymerase chain reaction (PCR)-based technology serves as a robust test to detect SARSCoV-2 in patients with COVID-19, there is a high demand for cost-effective, rapid, comfortable, and accurate point-of-care diagnostic tests in medical facilities. This review introduces the SARS-CoV-2 viral structure and diagnostic biomarkers derived from viral components. A comprehensive introduction of a paper-based diagnostic platform, including detection mechanisms for various target biomarkers and a COVID-19 commercial kit is presented. Intrinsic limitations related to the poor performance of currently developed paper-based devices and unresolved issues are discussed. Furthermore, we provide insight into novel paper-based diagnostic platforms integrated with advanced technologies such as nanotechnology, aptamers, surface-enhanced Raman spectroscopy (SERS), and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. Finally, we discuss the prospects for the development of highly sensitive, accurate, cost-effective, and easy-to-use point-ofcare COVID-19 diagnostic methods. |
| Keyword | COVID-19, SARS-CoV-2, Paper-based biosensors, Lateral flow assay (LFA), Point-of-care testing (POCT) |
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