| Info. | Vol.16 - No.4 (2022.12.20) |
|---|---|
| Title | Effect of Periodical Tensile Stimulation on the Human Skin Equivalents by Magnetic Stretching Skin-on-a-Chip (MSSC) |
| Authors | Kyunghee Kim1,2, Subin Jeong1,2, Gun Yong Sung1,2,3
*Gun Yong Sung gysung@hallym.ac.kr |
| Institutions | 1Interdisciplinary Program of Nano-Medical Device Engineering, Hallym University, Chuncheon 24252, Republic of Korea
2Integrative Materials Research Institute, Hallym University, Chuncheon 24252, Republic of Korea 3Major in Materials Science and Engineering, Hallym University, Chuncheon 24252, Republic of Korea |
| Abstract | The skin is the largest organ that protects the body from the outside and is subjected to constant physical stimulation, such as stretching. Although many studies currently focus on UV radiation and skin aging, few studies have been reported on the effects of excessive physical stimulation on the skin. We have developed a magnetic stretching skin-on-chip (MSSC) with a built-in electromagnet to apply magnetic field-based tensile stimulation. According to the 12-h cycle c ircadian locomotor output cycles kaput ( CLOCK ) gene expression, 5% tensile stimulation was added at 0.01 Hz for 12 h per day. Physical stress was applied during the 28 days of the skin regeneration cycle, and the tissue morphological changes, protein expression, and gene expression of skin equivalents were compared to previous study results of compressive stimulation (opposite mode of tensile) to confirm the effects. Comprehensively report the skin reaction depending on the type of stimulation. The expression of genes related to the epidermal barrier showed a similar tendency for both stimulation in the case of filaggrin, but the opposite tendency appeared for involucrin and keratin 10. The proteins that make up the dermis and epidermis also showed opposite trends in expression. |
| Keyword | Skin-on-chip, Tensile stimulation, Compressive stimulation, Skin barrier |
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