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Info. Vol.2 - No.4 (2008.12.20)
Title Nanomechanics of Biomolecules: A Review
Authors Y. Eugene Pak1, Mohana Marimuthu2 & Sanghyo Kim2
Institutions 1Corporate Technology Operation, Samsung Elecronics Co., Ltd., Maetan-dong, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-742, Korea
2Department of Bio-nano Technology, Kyungwon University, #San 65 Bokjung-dong, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, Korea
Correspondence and requests for materials should be addressed to S. Kim (samkim@kyungwon.ac.kr)
Abstract Nowadays it is possible to manipulate biopolymers such as DNA and protein, in ways to observe at single molecule level, as well as to touch and move, stretch, and crush individual molecules. An increasing number of inter and intramolecular interactions can be probed using single molecule manipulation techniques. Apart from inter- and intra-molecular interactions, the charged molecules interaction with substrates plays a vital role in designing nanobiosensors. Furthermore, the nanomechanical response which is the bending motion via changes of the surface stress produced due to biomolecular interactions over the surface of cantilever has also been studied interestingly by researchers. This review article exemplifies nanomechanical approaches in the analysis of viral packaging, biomolecular interactions, protein folding and unfolding, and DNA sequencing, illustrating how biomolecules contributes to the potential of exploiting novel concepts in technological innovation.
Keyword Viral packaging, Biomolecular interactions, Protein folding, Unfolding, DNA sequencing
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