| Info. | Vol.17 - No.2 (2023.06.20) |
|---|---|
| Title | From Single-to Multi-organ-on-a-Chip System for Studying Metabolic Diseases |
| Authors | Minjeong Jang 1, Hong Nam Kim 1,2,3,4* *Hong Nam Kim hongnam.kim@kist.re.kr |
| Institutions | 1 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
2 Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea 3School of Mechanical Engineering, Yonsei University, Seoul 03722,Republic of Korea 4Yonsei-KIST Convergence Research Institute, Yonsei University , Seoul 03722, Republic of Korea |
| Abstract | Metabolic diseases have been a major public health issue and a clinical challenge worldwide. Dysfunction of metabolic homeostasis is linked to the onset of various diseases because the various metabolizing organs synchronously interact to maintain metabolic homeostasis. Therefore, understanding inter-organ communication is important to develop more accurate drug testing and discovery for the treatment of metabolic diseases. The physiologically relevant organ-on-a-chip system is an emerging technology to study metabolic dynamics by providing an organ-level platform. This review summarizes the single- and multi-organ chip systems to study metabolic diseases and their dynamics, focusing on their inter-organ crosstalk. |
| Keyword | Organ-on-a-chip, Metabolic disease, Diabetes mellitus, Obesity, Non-alcoholic fatty liver disease |
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