| Info. | Vol.17 - No.2 (2023.06.20) |
|---|---|
| Title | Surface Modification Strategies for Biomedical Applications : Enhancing Cell–Biomaterial Interfaces and Biochip Performances |
| Authors | Soonjong Roh1,2 , Yerim Jang 3,4 , Jin Yoo1,5*, Hyejeong Seong 3,5* *Jin Yoo jyoo@kist.re.kr *Hyejeong Seong h.seong@kist.re.kr |
| Institutions | Soonjong Roh and Yerim Jang have equally contributed to the
manuscript. 2Department of Applied Bioengineering, Graduate School of Convergence Science and Technology , Seoul National University, Seoul 08826, Republic of Korea 3Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea 4KU-KIST Graduate School of Converging Science and Technology, Korea University ,Seoul 02841,Republic of Korea 5Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea |
| Abstract | Surface modification techniques are crucial in biomedical applications as they determine the direct response to the biological environment against the interfacing materials. Physical and chemical modification techniques have been extensively studied, with the latter being more commonly used due to the need for molecularly thin layers. Achieving uniform and conformal surface coverage on target geometries is critical to optimizing sensor and biomedical applications. However, achieving molecularly thin layers is practically challenging, and thick layers can alter the original properties of the bulk material. Furthermore, delamination of coated layers in humid or aqueous environments is also a concern, which can be prevented by covalent bonding of the functional groups on the substrate or incorporating appropriate functional groups or charges for solid adhesion. In this review, we provide an overview of the consolidated techniques for surface modification of materials for biomedical applications, including protein immobilization, chemical grafting, thin film coating, and plasma treatments. It also discusses the most frequently used surface modification techniques and their applications in the field. Overall, optimiz-ing surface engineering for each case is crucial, even if the method is the same, to achieve a uniform and conformal surface coverage on target geometries for various biomedical devices, sensors, and implants. |
| Keyword | Surface modification, Biomaterials, Biointerface engineering, Biosensors, Antifouling |
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