| Info. | Vol.17 - No.3 (2023.09.20) |
|---|---|
| Title | The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics |
| Authors | Junbeom Kim1,2, Mina Kim 1,3 , Ji Yoon Kang 1,4, Ki Wan Bong 2* , Nakwon Choi 1,3*
Junbeom Kim : First author. *Ki Wan Bong bong98@korea.ac.kr *Nakwon Choi nakwon.choi@kist.re.kr |
| Institutions | 1Brain Science Institute, Korea Institute of Science and Technology (KIST),Seoul 02792,South Korea
2Department of Chemical and Biological Engineering, Korea University, Seoul 02841, South Korea 3KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841,South Korea 4Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, South Korea |
| Abstract | Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal microRNAs (miRNAs), which are remarkably stable because of the protection by extracellular vesicles (EVs), in liquid biopsy have gained considerable attention as they can regulate gene expression and serve as crucial biomarkers for the presence and progression of different types of cancer. Especially, urinary exosomal miRNAs have shown promising results as biomarkers for cancer from the urogenital system, such as bladder, renal tubular, and prostate. However, there are still significant challenges hindering the clinical utilization of urinary exosomal miRNA biomarkers, including improper sample handling, and data bias. Therefore, the detection procedure of urinary exosomal miRNAs needs to be standardized and thoroughly reviewed to ensure accurate and reliable clinical results. In this review, we have explored various detection procedures for urinary exosomal miRNAs, which have great potential as biomarkers for cancer diagnostics and prognostics. |
| Keyword | Liquid biopsy, Cancer, Extracellular vesicle (EVs), Exosomal miRNAs, Urinary exosomal miRNAs |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
